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The 1 article that described long-term follow-up of the MSH participants reported 3 cases of cancer, 2 of which occurred in the hydroxyurea group ().
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Therefore, it was suggested that the effect of honey on wound healing may in part be related to the stimulation of inflammatory cytokines from monocytic cells (18, 25, 64, 65).
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Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality.
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Yet many deaths from SCD occur in early childhood, deaths that might be prevented by an effective, disease modifying intervention.
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Of the people with MS, 36 women and six men experienced their first symptoms at an average age of 45 years an average 15 years after their blood was collected.
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A similar pattern of lower metabolism in these same brain regions was seen in study participants with high blood sugar levels.
HYDREA (hydroxyurea) should not be exposed to it.
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Guideline for the management of acute and chronic pain in sickle-cell disease.
Presumably with once-daily dosing in SCA, hydroxyurea causes intermittent cytotoxic suppression of erythroid progenitors and cell stress signaling, which then affects erythropoiesis kinetics and physiology and leads to recruitment of erythroid progenitors with increased HbF levels.
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Hydroxyurea may also have a role for prevention and treatment of organ dysfunction, and these potential benefits are currently under active investigation.
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Although it is the most severe of the common sickle cell diseases (which include hemoglobin SC disease and sickle β 0-thalassemia), patients with sickle cell anemia have a wide spectrum of clinical manifestations.
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These results lend support to the possibility that the microfluidic platform developed here offers a unique and quantitative approach to assess the kinetic, rheological, and hematological factors involved in vasoocclusive events associated with SCD and to develop alternative diagnostic tools for disease severity to supplement other methods.
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The journal Pediatrics has published the first study to look at the costs and health outcomes (cost-effectiveness) of hydroxyurea (HU) treatment in young children with sickle cell disease (SCD).